Facility Agriculture: Intelligent Sensors【Department of Electrical Engineering / Wen, Chih-Yu / Distinguished Professor】  
設施農業：智慧感測【電機工程學系/溫志煜特聘教授】
論文篇名 A Pervasive Pulmonary Function Estimation System with Six-Minute Walking Test
期刊名稱 BIOSENSORS
發表年份,卷數,起迄頁數 2022; 12(10), 824.
作者 Wu, Ming-Feng; Teng, Chi-Min; Kuo, Tz-Hau; Huang, Wei-Chang; Wen, Chih-Yu(溫志煜)*
DOI 10.3390/bios12100824
中文摘要 肺活量測量法的自我監測有利於評估肺部疾病的進展和肺部康復的效果。然而，普適性肺活量測定法未能同時滿足準確性和可重複性的實施標準。本研究旨在提出一種具有六分鐘步行測試（6MWT）的普遍肺活量測定估計系統，該系統具有資訊管理，通信協定，預測演算法和腕戴式設備。透過在進行步行測試之前和之後測量肺功能、步行距離和生理狀態資訊，從中提取重要變數以預測用力肺活量（FVC）和用力呼氣量（FEV1）。本研究創建了FVC，FEV1與6MWT的預測模型，並將這些預測公式實現於腕戴式設備中。所開發的肺功能估計系統腕帶原型已被證明可以提供有效的自我估計，對於那些無法進行普適性居家肺活量測定法的人來說，這將是一個同時具有準確性和可重複性的FVC和FEV1自我評估工具。
英文摘要 Self-monitoring for spirometry is beneficial to assess the progression of lung disease and the effect of pulmonary rehabilitation. However, home spirometry fails to meet both accuracy and repeatability criteria in a satisfactory manner. The study aimed to propose a pervasive spirometry estimation system with the six-minute walking test (6MWT), where the system with information management, communication protocol, predictive algorithms, and a wrist-worn device, was developed for pulmonary function. Pulmonary function test, walking steps, and physical status were measured before and after performing the 6MWT. The significant variables were extracted to predict per step distance (PSD), forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). These predicted formulas were then implemented in a wrist-worn device of the proposed pervasive estimation system. The predicted models of PSD, and FVC, FEV1 with the 6MWT were created. The developed wristband prototype of the pulmonary function estimation system was demonstrated to provide effective self-estimation. This is a potential tool for self-estimation on FVC and FEV1 for those who cannot conduct home-based spirometry.
發表成果與本中心研究主題相關性 肺功能檢查是反映呼吸系统疾病發生、發展狀態較客觀的指標之一。雖然家畜動物肺功能檢測與人類肺功能檢測指標類似，在獸醫領域目前仍缺乏呼吸/肺功能評估之廣泛應用。獸醫學上已發展出具有可直接測量肺順應性與氣道阻力之方法來獲取通氣機械性相關資料，然而這樣的測量方式需要中度或全身麻醉與插管，對罹患呼吸系統疾病的家畜大動物(如: 豬、馬、牛、羊等)與小動物(如: 貓、犬、兔、鼠等)臨床病患而言具有風險。本研究雖然著重於人類肺功能檢測，但以某些特定參數評估疾病嚴重度以及監測治療反應的概念，藉由定性與定量的呼吸訊號，或許可以延伸應用以評估動物肺功能呼吸系統/肺的機械性，進而實現非侵入性的家畜動物呼吸肺功能檢測方法。