新穎材料農業：友善環境農業新穎材料研發與安全評估【材料科學與工程學系/薛涵宇副教授】
| 論文篇名 | 英文：Sol–Gel-Derived Hierarchically Wrinkled Mesoporous Ceramics for Enhancement of Cell Alignment 中文：界面溶凝膠反應誘導生成多尺度介孔陶瓷皺褶表面用於細胞排整 |
| 期刊名稱 | Chemical Engineering Journal |
| 發表年份,卷數,起迄頁數 | 2021, 405, 126572 -126583 |
| 作者 | Xie, Yi-Ting; Chen, Jun-Rong; Chen, Yu-Ting; Jiang, Bing-Cheng; Sie, Zong-Han; Hsu, Han-Yi; Chen, Ting-Lun; Chiang, Ya-Yu; Hsueh, Han-Yu(薛涵宇)* |
| DOI | 10.1016/j.cej.2020.126572 |
| 中文摘要 | 多尺度陶瓷結構因其親水性的本質與較佳的環境抗性，在工業應用具極大的應用潛力，然而，迄今為止，製備多尺度陶瓷結構多需特定且昂貴的真空設備(例如，物理(PVD)或化學(CVD)氣相沉積系統)與耗時的過程，這些限制了多尺度陶瓷結構的實際應用，為此，我們結合了界面之濕式溶膠-凝膠反應(sol-gel reaction)與彈性體交聯收縮引起自發皺褶生成，進而產生有序陶瓷皺褶表面，系統性地控制溶膠-凝膠反應的參數，包括前驅鹽，酸/鹼催化劑，老化時間和反應溫度，以製備表面無裂痕之陶瓷皺褶表面，換言之，我們開發了一種簡單、無模板、大面積、且多尺度之陶瓷皺紋形成工藝，它可以用於許多實際應用中，例如細胞排整、微流控芯片、防滑表面、防眩光結構和光電元件。在本研究中，該生物友善之多尺度SiO2陶瓷皺褶表面顯示出對人類血管細胞排整具增強的效果，有助於細胞生長排列。 |
| 英文摘要 | Hierarchical ceramic structures offer great potential for multitudinous industrial applications (e.g., cell alignment) due to their intrinsic hydrophilic and environmental resistance properties. However, to date, the fabrication of hierarchical ceramic structures requires specific equipment (e.g., high vacuum systems) and time-consuming processes; such requirements limit the practical utilization of hierarchical ceramics. In this study, we combined ceramic thin films produced from interfacial sol–gel reactions and surface wrinkling from elastomer cross-linking contraction; we conducted a dynamic interfacial release process to fabricate hierarchically wrinkled mesoporous ceramic surfaces on soft elastomers. The parameters of sol–gel reactions, including precursors, acid/base-catalysts, aging time, and temperature, were systematically controlled to demonstrate the feasibility of sol–gel reactions for fabrication of hierarchically mesoporous ceramic wrinkled surfaces (i.e., mesopores on a microsized wrinkled surface). Furthermore, the wrinkled surfaces demonstrated great enhancement of growth alignment of human blood vessel cells. Thus, we developed a simple (yet cost-effective), mold-free, large-area, and hierarchical ceramic wrinkle formation process; it can be used in many practical applications, such as cell culture, microfluidic chips, anti-skidding surfaces, antiglare structures, and photoelectric devices. |
| 發表成果與本中心研究主題相關性 | 此研究開發一新穎製程, 著重於誘導細胞排整, 除了誘導植物孢子等細胞排整外, 更可誘導動物細胞, 如幹細胞與血管細胞的排整, 對於畜產動物體內組織重建具有應用潛力。 |
