循環農業：農業廢棄物高價值化【李進發特聘教授】
論文篇名 英文：Syntheses of Thioethers and Selenide Ethers from Anilines
中文：由苯胺合成硫醚和硒醚
期刊名稱 The Journal of Organic Chemistry [IF=4.745; 7/57 =12.28% (Q1)]
發表年份,卷數,起迄頁數 2019, 84, 6223−6231
作者 Yi-Chen Shieh,Kai Du, R. Sidick Basha, Yung-Jing Xue,Bo-Hao Shih, Liang Li, and Chin-Fa Lee
DOI  10.1021/acs.joc.9b00322
中文摘要 在這項研究中，提出了在無溶劑和無過渡金屬的條件下從苯胺合成硫醚和硒醚的通用程序。
英文摘要 In this study, a general procedure was proposed for synthesizing thioethers and selenide ethers from anilines under solventfree and transition-metal-free conditions. Thioethers were formed when anilines reacted with thiols under blue light-emitting-diode (LED) irradiation at room temperature without a photocatalyst. When reactions were performed using anilines and diselenides, the corresponding selenide ethers were obtained with satisfactory to excellent yields. The reaction was performed under photocatalyst-free and solvent-free conditions without blue LEDs. The advantages of this system include convenient operations, mild reaction conditions, satisfactory functional group tolerance, and late-stage selenylation of drug molecules.