【學術亮點】Rubber-band-like polymeric nanotoroids’ preparation and their agile effects in anticancer drug delivery
Facility Agricultural: Utilization of Livestock Waste in Automated Cultivation of Microalgae and Reutilization in Poultry Farming【Department of Forestry / Chen, Yi-Chun / Professor】
設施農業：畜牧廢棄物於小球藻自動栽培與禽類再利用【森林學系/陳奕君教授】
| 論文篇名 | 英文：Rubber-band-like polymeric nanotoroids’ preparation and their agile effects in anticancer drug delivery 中文：橡膠圈狀高分子奈米環的製備及其在抗癌藥物傳遞中智慧效應 |
| 期刊名稱 | Nanotoday |
| 發表年份,卷數,起迄頁數 | 2025, 65, no.102862 |
| 作者 | Jiang, Wen-Ping1; Chen, Yi-Chun(陳奕君) 1; Chiang, Ya-Yu1; Yu, Chung-Ping1; Lin, Hui-Chang; Chen, Jiann-Yeu; Huang, Guan-Jhong; Chiu, Hsin-Cheng; Chung, Chieh-Yu; Hsieh, Min-Tsang*; Chiang, Yi-Ting* |
| DOI | 10.1016/j.nantod.2025.102862 |
| 中文摘要 | 本研究開發了一種具備靈活性且可接合抗癌藥物的環狀混合微胞（Toroidal mixed micelle, TMM）平台。透過高速即時顯微觀察，發現載藥TMM在靜止與流動條件下均表現出如橡皮筋般的動態變形特性。顯微結果顯示，球形混合膠束（Spherical mixed micelle, SMM）在靜態或流動條件下均可被細胞內吞；而TMM僅在與細胞接觸並發生表面擴張時被攝取，導致巨噬細胞對TMM的總體攝取量顯著降低。TMM的「靈活效應」使其在靜態下具有卓越的腫瘤球體滲透能力，並在流經微孔時展現出優異的擠出性。動物體內實驗進一步證實，TMM能有效穿透破裂血管、聚集於腫瘤組織，並避免被肝臟與脾臟的巨噬細胞吞噬。此平台成功在腫瘤深層清除癌細胞而不損害肝脾組織；相比之下，SMM因主要沉積於血管周圍，腫瘤抑制效果較差。綜合結果顯示，TMM平台具備優異的抗癌藥物傳遞潛力，為癌症治療提供新型且高效的傳輸藥物系統。 |
| 英文摘要 | In this study, an agile anticancer drug-conjugatable toroidal mixed micelle (TMM) platform was developed. When observed under a high-speed real-time microscope, the drug-loaded TMMs exhibited dynamic transformation, displaying rubber-band-like characteristics under both static and flow conditions. Microscopic observations revealed that the spherical mixed micelles (SMMs) were internalized by cells upon their attachment in a static state or under flow conditions, whereas the TMMs were taken up by the cells only when coming into contact with expanding surfaces during their dynamic transformation. This effect resulted in a reduction in the total cellular uptake of TMMs by macrophage cells. In addition, the agile effect of TMMs affords them an exceptional ability to penetrate tumor spheroids in a static state and imparts exceptional extrusive ability when they flow through small pores. The in vivo studies conducted in this work demonstrate their superior ability to penetrate ruptured blood vessels, accumulate in tumor lesions, and avoid macrophage uptake into the liver or spleen. These in vivo studies also indicate that the TMMs eliminated cancerous cells deep within tumors while causing no injury to the liver and spleen, while SMMs displayed suboptimal tumor inhibition, due to their deposits in the proximity of blood vessels. Our TMM platform is feasible as a drug delivery system in anticancer applications. |
| 發表成果與本中心研究主題相關性 | 環狀混合微胞（TMM）平台展現了高效率、低副作用的藥物傳輸特性，TMM 的可控制釋與靈活性可作為藻類培養或微生物載體之設計啟發，反映出可延伸至農業與畜牧系統中「生物傳輸與控制釋放」的潛在應用概念。 |
