【學術亮點】Palladium-catalyzed reductive cross-coupling reaction of carboxylic acids with thiols: an alternative strategy to access thioesters
Recycling Agriculture: Valorization of Agricultural Residual Materials【Department of Chemistry / Lee, Chin-Fa / Distinguished Professor】
循環農業：農業剩餘資材及生質衍生物高值化轉換再利用【化學系/李進發特聘教授】
| 論文篇名 | 英文：Palladium-catalyzed reductive cross-coupling reaction of carboxylic acids with thiols: an alternative strategy to access thioesters 中文：鈀催化羧酸與硫醇的還原交叉偶合反應：獲取硫酯的另一種策略 |
| 期刊名稱 | Organic & Biomolecular Chemistry |
| 發表年份,卷數,起迄頁數 | 2025, 23(18), 4487–4496 | |
| 作者 | Chang, Yen-Ting; Bai, Rekha; Hsia, Yang-Ting; Karmakar, Indrajit; Badsara, Satpal Singh; Lee, Sunwoo; Lee, Chin-Fa(李進發)* |
| DOI | 10.1039/D5OB00151J |
| 中文摘要 | 本論文提出了一種實用且可行的合成硫酯的替代方法，利用易獲取的起始原料，例如羧酸和硫醇，在鈀催化下，透過直接還原C-S交叉偶聯反應製備硫酯。此方法具有良好的原子經濟性、優異的產率、廣泛的官能基耐受性、廣泛的底物適用性、操作簡便以及反應條件溫和，無需額外步驟等特點。 |
| 英文摘要 | A practical and alternative approach to access thioesters is presented, utilizing readily available starting precursors such as carboxylic acids and thiols via direct reductive C–S cross-coupling reactions under palladium catalysis. The present protocol features good atom economy, excellent yields, wide functional group tolerance, broad substrate scope, operational simplicity, and mild reaction conditions with no additional steps |
| 發表成果與本中心研究主題相關性 | 硫酯為一類重要的有機硫化物，因其獨特的化學結構和反應特性，在農業化學和工業等領域中具有廣泛應用。此論文開發一新型綠色反應合成硫酯。符合本中心研究主題相關性---發展永續綠色化學。 |
