Facility Agricultural Green Energy Development and Carbon Offset【Department of Bio-industrial Mechatronics Engineering / Wu, Ching-Chou / Professor】
設施農業：農業綠能開發與碳匯補償【生物產業機電工程學系/吳靖宙教授】
論文篇名 英文：Recent Advances in Electrochemical Immunosensors with Nanomaterial Assistance for Signal Amplification
中文：利用奈米材料輔助訊號放大之電化學免疫感測器的最新進展
期刊名稱 Biosensors
發表年份,卷數,起迄頁數 2023, 13, 125.
作者 Patil, Avinash V. Police V.; Chuang, Yu-Sheng; Li, Chenzhong; Wu, Ching-Chou(吳靖宙)*
DOI 10.3390/bios13010125
中文摘要 由於電化學免疫感測器的電極製作容易與微型電子讀取設備高度相容，有利於發展成即時診斷裝置。電化學免疫感測器可以分為無標記和有標記的感測策略，並藉由電位、電流、伏安或阻抗的檢測器進行免疫反應的量化。新興的奈米材料經常用於電化學免疫感測器上，作為電極的高粗糙度和高導電性的界面，或者作為固定捕捉抗體、電活性介質或催化劑的奈米載體。採用奈米材料可以提高免疫感測器的特性，降低檢測極限和提高靈敏度。最近的研究顯示了創新的奈米材料固定方法，以符合不同電化學免疫感測器的要求。本文回顧了過去五年來奈米材料（金屬奈米粒子、金屬奈米結構、碳奈米管和石墨烯）與電化學免疫感測器整合的進展。此外，本文還討論了基於奈米材料的電化學免疫感測器的新趨勢和努力。
英文摘要 Electrochemical immunosensors have attracted immense attention due to the ease of mass electrode production and the high compatibility of the miniature electric reader, which is beneficial for developing point-of-care diagnostic devices. Electrochemical immunosensors can be divided into label-free and label-based sensing strategies equipped with potentiometric, amperometric, voltammetric, or impedimetric detectors. Emerging nanomaterials are frequently used on electrochemical
immunosensors as a highly rough and conductive interface of the electrodes or on nanocarriers of immobilizing capture antibodies, electroactive mediators, or catalyzers. Adopting nanomaterials can increase immunosensor characteristics with lower detection limits and better sensitivity. Recent research has shown innovative immobilization procedures of nanomaterials which meet the requirements of different electrochemical immunosensors. This review discusses the past five years
of advances in nanomaterials (metal nanoparticles, metal nanostructures, carbon nanotubes, and graphene) integrated into the electrochemical immunosensor. Furthermore, the new tendency and endeavors of nanomaterial-based electrochemical immunosensors are discussed.
發表成果與本中心研究主題相關性 該回顧論文報導奈米材料或載體對電化學免疫感測器訊號放大的影響，免疫感測器在環境中重金屬、汙染源分子、細菌、動物健康指標蛋白與食品安全領域都有廣泛性的應用，經由奈米材料的輔助，可使免疫感測器應用於農業議題上的檢測更加靈敏與方便。