【學術亮點】胺和硫代膦酸酯之間的光或電化學N-P交叉異質脫氫偶聯
【學術亮點】Photo- or Electrochemical N-P Cross-Hetero-Dehydrogenative Couplings between Amines and Phosphonothioates
Recycling Agriculture: Valorization of Agricultural Residual Materials【Department of Chemistry / Lee, Chin-Fa / Distinguished Professor】
循環農業：農業剩餘資材及生質衍生物高值化轉換再利用【化學系/李進發特聘教授】
論文篇名 英文：Photo- or Electrochemical N-P Cross-Hetero-Dehydrogenative Couplings between Amines and Phosphonothioates
中文：胺和硫代膦酸酯之間的光或電化學N-P交叉異質脫氫偶聯
期刊名稱 Advanced Synthesis & Catalysis
發表年份,卷數,起迄頁數 2025, 367(10), no. e202401418
作者 Lee, Sung-Hung; Lu, Yu-Lin; Chiu, Yu-Lin; Hung, Hsiu-Te; Karmakar, Indrajit; Chen, Peter Ping-Yu; Lee, Chin-Fa(李進發)*
DOI 10.1002/adsc.202401418
中文摘要 我們提出了兩種不同的合成方法，用於合成功能各異的，分別採用光化學或電化學策略，透過N-P交叉異質脫氫偶聯反應。這兩種方法都提供了一個實用且高效的途徑來合成這類重要的生物相關硫代磷醯胺酯。此方案的主要優點包括反應條件溫和，使用可見光和電化學電池作為永續工具，以及透過低能可見光源和低電流操作實現的能源效率。此外，此製程採用低成本底物及無毒光敏劑，產率高，底物範圍廣，官能基耐受性優異，操作簡便，且非常注重環保。硫代磷酰胺酯
英文摘要 We present two distinct synthetic approaches for the synthesis of diversely functionalized thiophosphoramidates, employing either photochemical or electrochemical strategies via N-P cross-heterodehydrogenative coupling. Both methods provide a practical and efficient route to access this significant class of biologically relevant hiophosphoramidates. Key advantages of the protocol include mild reaction conditions, the use of visible light and electrochemical cells as sustainable tools, and energy efficiency enabled by a low-energy visible light source and low-current operation. Furthermore, the process utilizes low-cost substrates and a nontoxic photosensitizer, delivers high yields, exhibits broad substrate scope with excellent functional group tolerance, and offers operational simplicity with a strong emphasis on eco-friendliness.
發表成果與本中心研究主題相關性 硫代磷酰胺酯作為一類重要的有機硒化物，因其獨特的化學結構和反應特性，在農業化學和材料等領域中具有廣泛應用。此論文開發一新型綠色反應合成硫代磷酰胺酯。