【學術亮點】Transition Metal-Free P-Se Oxidative Cross-Coupling for the Synthesis of Phosphoroselenothioates and Phosphoroselenoates
Recycling Agriculture: Valorization of Agricultural Residual Materials【Department of Chemistry / Lee, Chin-Fa / Distinguished Professor】
循環農業：農業剩餘資材及生質衍生物高值化轉換再利用【化學系/李進發特聘教授】
| 論文篇名 | 英文：Transition Metal-Free P-Se Oxidative Cross-Coupling for the Synthesis of Phosphoroselenothioates and Phosphoroselenoates 中文：硫代亞磷酸酯與二硒化合物的有氧氧化交叉脫氫偶聯反應 |
| 期刊名稱 | Asian Journal of Organic Chemistry |
| 發表年份,卷數,起迄頁數 | 2025, 14(12), e70223 |
| 作者 | Sung-Hung Lee, Indrajit Karmakar, Hsiu-Te Hung, Rekha Bai, Chin Chang, Mi-Zuo Huang, Kuan-Yu Lin and Chin-Fa Lee* |
| DOI | 10.1002/ajoc.70223 |
| 中文摘要 | 我們以氧氣為氧化劑，成功地利用碳酸銫催化，使硫代亞磷酸酯與二硒化合物進行高效的氧化偶聯反應。此方法官能基耐受性良好，反應條件簡單溫和，沒有什麼副產物，也不需要高溫或是過渡金屬催化，有利於生物活性分子的合成與修飾。 |
| 英文摘要 | We report a one-pot, transition metal-free oxidative P-Se cross-coupling reaction for the synthesis of Se-phosphoroselenothioates/phosphoroselenoates under ambient conditions. The reaction between phosphonothioates/phosphonates and diaryl diselenides proceeds efficiently within 3 hours in acetonitrile under an oxygen atmosphere, using Cs2CO3 as a non-toxic base. This method stands out for its practical utility, combining a broad substrate scope, ease of operation, and scalability to gram-level synthesis. Featuring a clean reaction profile and environmentally benign conditions, this method holds great promise for academic and industrial settings, providing a sustainable and cost-efficient solution. |
| 發表成果與本中心研究主題相關性 | 硒代磷酸酯作為一類重要的有機硒化物，因其獨特的化學結構和反應特性，在農業化學和工業等領域中具有廣泛應用。此論文開發一新型綠色環保製程合成硒代磷酸酯。尤其在農業用途上，減少汙染物的生成! |
